Alere Epoc Value Assignment Full Set Of#
Alere Epoc Value Assignment Portable Analyzers VetStat#

If the Commission finds that the remedies are proportionate to, and entirely eliminate those competition concerns, it can issue a merger clearance decision, declaring the concentration compatible with EU law (Recital 30, EU Merger Regulation).Siemens Healthineers has entered into a definitive agreement to acquire Epocal Inc., a subsidiary of Alere Inc. The parties may propose remedies (also known as commitments) in order to meet specific competition objections raised by the Commission. Format ( ticker )) print ( response.

Alere Epoc Value Assignment Portable Analyzers VetStat

The VetStat analyzer may be useful in performing blood gas analysis in equine samples but analysis of , and pO 2 should be interpreted with caution. The VetStat analyzer yielded results that were in agreement with the cobas b 123 analyzer for determination of pH, pCO 2, bicarbonate () and potassium concentration , while the epoc analyzer achieved acceptable agreement for and. Limits of agreement indicated relevant bias between the VetStat and cobas b 123 for partial pressure of oxygen (pO 2 27.5вЂ“33.8 mmHg), sodium ( 4.3вЂ“21.6 mmol/L) and chloride concentration ( 0.3вЂ“7.9 mmol/L) and between the epoc and cobas b 123 for pH (0.070вЂ“0.022), partial pressure of carbon dioxide (pCO 2 3.6вЂ“7.3 mmHg), pO 2 (36.2вЂ“32.7 mmHg) and (0.38.1 mmol/L). Blood gas analysis and electrolyte concentrations measured by the portable analyzers VetStat and epoc were compared to those produced by the cobas b 123 analyzer via concordance analysis, Passing-Bablok regression and Bland-Altman analysis. Blood samples from 23 horses hospitalized for various medical reasons were included in this prospective study. The aim of this study was to determine whether 2 portable analyzers produce results in agreement with a stationary analyzer.

Alere Epoc Value Assignment Full Set Of

Funding: The authors received no specific funding for this work.Competing interests: One of the authors (KK) is employed by an institution that has received sponsorship by IDEXX. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Data Availability: Full set of data available at. Katz, University College Dublin, School of Veterinary Medicine, IRELANDReceived: December 12, 2017 Accepted: January 8, 2019 Published: February 15, 2019Copyright: В© 2019 Kirsch et al. PLoS ONE 14(2):Editor: Lisa M.

In this study it was revealed that performance of the POC devices was good for some parameters, while insufficient for other parameters. However, not all POC devices give comparable results as shown by a recent study comparing 2 POC blood gas analyzers to a stationary one in horses. The utilization of portable Point-of-Care (POC) devices provides immediate measurement results for stall-side testing in the clinic and in a field setting. Monitoring of acid-base and electrolyte status in exercising horses is also of clinical use with horses undertaking high-intensity exercise such as racing, eventing or endurance competitions often developing alterations in acid-base and electrolyte status leading to disorders such as exercise-induced dehydration, cardiac dysrhythmias, laminitis or exertional rhabdomyolysis. Assessment of acid-base and electrolyte concentration also provides useful information for the diagnosis and management of metabolic disorders in critically ill horses , horses with gastrointestinal disorders and hereditary conditions (e.g., hyperkalemic periodic paralysis, recurrent exertional rhabdomyolysis) in which alterations of blood electrolyte concentrations are commonly observed. Arterial blood gas analysis enables the assessment of pulmonary oxygenation efficiency and ventilation status , which may be of clinical value for the monitoring of patients under general anesthesia, patients with thoracic or respiratory diseases as well as critically ill neonates.

The epoc reader runs a calibration cycle for each cassette, containing an integrated quality control system with specific reference liquids for this machine. All machines were kept at constant room temperature for at least 24 hours before and during the experiments. The is calculated by means of the Henderson-Hasselbalch equation in all 3 instruments.All analyzers were calibrated, maintained and operated according to their manufacturerвЂ™s instructions. The POC blood gas analyzer VetStat determines the blood gas partial pressures and electrolyte concentrations by measuring their optical fluorescence using optodes. The pO 2 is measured via an amperometric method with ion-selective electrodes of the Clarke type. The epoc analyzer requires a sample volume of 95 ОјL and takes less than 1 minute, while the VetStat analyzer requires a sample volume of 125 Ојl and takes less than 2 minutes for sample analysis.The stationary POC system cobas b 123 and the POC analyzer epoc determine pH, pCO 2 and electrolyte concentrations via a potentiometric method using ion selective electrodes and the Nernst-equation.

The intercept of the Passing-Bablok regression equation reflects the constant bias, the slope reflects the proportional bias and the residual standard deviation (RSD) reflects the random bias. A value of в‰¤ 0.90 was considered to be poor agreement, 0.90вЂ“0.95 as moderate agreement, 0.95вЂ“0.99 as substantial agreement and в‰Ґ0.99 as almost perfect agreement between methods. LinвЂ™s concordance correlation coefficient (r ccc) contains a measure of precision (PearsonвЂ™s ПЃ) and accuracy (bias corrected factor, C b) and was used as an indicator for the strength of concordance between measurements. The system calibration runs once a day in the morning with a 1 point-calibration running every 60 minutes, and a 2-point-calibration, running every 8 hours these are postponed if the system starts a cycle during analyses.Concordance correlation analysis, Passing-Bablok regression analysis and the Bland-Altman method (MedCalc Statistical Software version 16.1, Ostend, Belgium) were performed to determine agreement between the 3 analyzers. The cobas b 123 system runs automated calibration cycles at defined intervals. Internal calibration and quality control processes are performed by the reader with the VetStat reader calibrated with standard reference cassettes, standard hemoglobin cassettes and standard gas cartridges at prescribed intervals.

To warrant the validity of the Passing-Bablok procedure, the linear relationship between compared results was assessed by the cusum test.In addition to regression analysis, Bland-Altman plots were prepared by plotting the difference between 2 compared measurements against the mean of the 2 measurements. Assuming normal distribution, 95% of random differences are expected to lie within В± 1.96 RSD, with a large interval considered to indicate a high imprecision. For the slope, a 95% CI including the value 1 means that there is no significant difference between the obtained slope value and the value 1 and that there is no significant proportional bias between two methods. Therefore, if the 95% CI includes the value 0 for the intercept it can be assumed that there is no significant difference between the obtained intercept value and the value 0 and therefore no constant bias between the 2 methods.

Repeatability for each analyzer was assessed using the mean, the within-run standard deviation (SD w-run) and the within-run coefficient of variation in percent (CV w-run). The assignment of limits for clinical acceptance were based on the CLIA guidelines.